To investigate the relationship between TNS3 and cancer, we investigated TCGA database and found that TNS3 is lower expressed in many types of cancer, including adrenocortical carcinoma (ACC), CESC, kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), thyroid carcinoma (THCA), and UCEC (Fig. 6A). This evidence concerns the gene TNS3 and adrenal cortex carcinoma.