Moreover, we cotransfected GIST cells with the miR-130a inhibitor and the ATG2B siRNA, and the results of a CCK-8 assay demonstrated that the downregulation of ATG2B increased the chemosensitivity of GIST cells to imatinib and the function of miR-130a is reversed after downregulating ATG2B (Fig. 5E). Here, ATG2B is linked to gastrointestinal stromal tumor.