HOTAIR and digestive system neoplasm: Furthermore, although there is no lncRNA expression database for GISTs, the research significance of HOTAIR was confirmed by the overall survival curves obtained from the GEPIA database regarding the high expression of HOTAIR in several types of gastrointestinal tumors, including stomach adenocarcinoma, colon adenocarcinoma, esophageal carcinoma, rectal adenocarcinoma (Fig. 1C).