HDAC6 and non-small cell lung carcinoma: To confirm the above finding, H460 and A549 NSCLC cells were treated with various noncytotoxic concentrations of trichostatin A (TSA), an inhibitor of HDAC6, which is a dominant enzyme required for the removal of the acetyl group from α-tubulin, to minimize the interference of this factor in cell death (Supplementary Fig. 1).