IL18 and neoplasm: Several evidences indicate that the pattern and balance of pro-inflammatory cytokines, including IL-1α, IL-1β, IL-6, IL-12, IL-18, IL-23 and TNF-α, among others, play a crucial role shaping protumor and antitumor immunity and thereby the development of tumorigenesis63, as reflected in the differential tumor phenotype of p53 KO and HEM mice.