To provide evidence for endogenous CARD10 cleavage by MALT1, we used A549 human lung carcinoma cells, which express detectable CARD10 levels10,43, and we immunoprecipitated CARD10 following phorbol ester/ionomycin treatment (P/I) to activate PKC isoforms44. The gene discussed is PRRT2; the disease is lung carcinoma.