The infarct sizes in MI and MI + vehicle group were significantly increased compared with those in the sham group (P < 0.01, Fig. 3E, F); however, CREG protein significantly reduced the infarct size (20.14 ± 0.89% vs. 30.76 ± 0.93%, respectively; P < 0.01, Fig. 3E, F). The gene discussed is CREG1; the disease is infarction.