Although the role of EMT in GBM is controversial due to brain plasticity, its non-epithelial characteristics, similarity with astrogliosis and the mesenchymal profile of most GBMs46,68, it is accepted that GBM cells can acquire a more mesenchymal phenotype55–57, associated with high Vimentin levels, invasiveness, and poor prognosis. The gene discussed is VIM; the disease is glioblastoma.