To explore whether the tumor suppressive effect in pancreatic cancer of miR-30d was mediated by SOX4, we first constructed miR-30d-overexpressing Mia PaCa-2 and Panc-1 cells by transfection lentivirus of Lv-miR-30d or control vectors, then overexpressed SOX4 by transfection of Lv-SOX4 lentivirus vector. The gene discussed is SOX4; the disease is familial pancreatic carcinoma.