We also observed that the promotive effects of ADCK1 on cell invasion and anchorage-independent growth depended on the Wnt/β-catenin signaling pathway (Fig. 6E, F), indicating that ADCK1 promoted the malignant phenotypes of colon cancer cells by activating the Wnt/β-catenin signaling pathway. Here, ADCK1 is linked to malignant colon neoplasm.