Cytokines and myeloid cells appear to play a significant role in CAR-T cell induced neurotoxicity as reports have shown significant increases of CD14+ cells in patients with grade 3 or higher neurotoxicity97 and a pivotal large B cell lymphoma CAR-T cell clinical trial showed that among serum biomarkers associated with development with grade 3 or higher neurotoxicity, GM-CSF elevation was most significantly associated with neurotoxicity3. This evidence concerns the gene CD14 and B-cell non-Hodgkin lymphoma.