KMT2E and acute promyelocytic leukemia: Gene ontology analysis for terms present in both MLL5high APL patients and H3K4me3 ATRA only were associated with “Positive regulation of cytokine production”, “cell differentiation” and “regulation of apoptotic process”, suggesting that APL patients with high MLL5 expression presented an intrinsic biology more compatible with ATRA-induced changes on H3K4me3 (Supplementary Table 3).