Subsequent, gene set enrichment analysis (GSEA) associated MLL5high APL patients with the terms “Retinoic acid binding”, “Myeloid leukocyte differentiation” and “Cellular response to retinoic acid”, while low MLL5 APL patients were associated with “negative regulation of cell cycle”, “17-leukemic stem cell markers” and “genes up-regulated upon PHF8 knockdown” (Fig. 1E). Here, PHF8 is linked to acute promyelocytic leukemia.