TMC1 and deafness: The homologous human deafness mutation is TMC1 p.M418K (Zhao et al., 2014b; Wang et al., 2018), the mutation site is adjacent to two other missense mutations causing deafness: TMC1 p.L416R (Chen et al., 2015) and TMC1 p.G417R (Yang et al., 2010).