VEGFA and hypertensive disorder: Although the exact mechanism of VEGF inhibitor-induced hypertension is not entirely understood, potential mechanisms have been proposed [43, 44]: oxidative stress and endothelial dysfunction [45], an imbalance between vasodilators (decrease in nitric oxide and prostacyclin I) and vasoconstrictors (increase in endothelin) [46], vascular remodeling, capillary rarefaction [47] and decreased renal excretion of sodium [48].