Tooth-associated defects, such as short roots with thin dentin, lack of acellular cementum, and alveolar bone loss, are the most common clinical manifestations of patients with HPP [1, 23, 24, 34, 35], and these phenotypes were also found in ALPL knockout mice or condition ALPL knockout mice [11, 27, 36]. Here, ALPL is linked to hypophosphatasia.