FOXP3 and neoplasm: Nuclear localized SMAD2/3/4 complex induces tumor-promoting effects through cell proliferation (PDGF-β), immune suppression (Foxp3), EMT activation (SNAIL/SLUG, ZEB1/ZEB2, HMGA2), EMT suppression (E-Cadherin, Cytokeratin) and metastasis (HDM2, MMP-9).