CD274 and cervical cancer: While pembrolizumab received accelerated FDA approval based upon ORR and duration of response (DOR) for patients with recurrent/metastatic cervical cancer with tumors that express PD-L1, the ORR of 14.3% suggests that there remains a significant unmet need for patients with previously treated advanced cervical cancer unselected for PD-L1. A multi-center, global single-arm phase II study (NCT04246489) will assess the clinical activity and safety profile of Bintrafusp alfa in platinum-experienced cervical cancer [117].