In accordance with these findings, our study shows that exosomes elicited in tumor cells after the first cycle of chemotherapeutic stimulation are responsible for the subsequent chemotherapeutic insensitivity mediated by the delivery of miR-378a-3p and miR-378d targeting the WNT pathway inhibitor DKK3 and the Notch pathway suppressor NUMB. The gene discussed is NUMB; the disease is neoplasm.