Although there are few studies using CD200 or CD200R1 KO mice, especially in the context of the CNS, an accelerated microglial response or a worse outcome of the pathology in CD200 KO mice has also been described in experimental models of neuronal damage such as experimental autoimmune uveoretinitis, encephalitis, facial nerve transection or experimental autoimmune encephalomyelitis (EAE) [5, 17, 26] and in stroke in CD200R1 mice [65]. This evidence concerns the gene CD200R1 and experimental autoimmune encephalomyelitis.