CD200R1 and experimental autoimmune encephalomyelitis: By contrast, when CD200R1 is blocked, an exacerbation of microglial activation and dopaminergic neurodegeneration in 6-OHDA-treated rats has been described [87], as well as increased dopaminergic neuron death in the LPS model of PD [83] and a worse outcome in experimental autoimmune encephalomyelitis [55].