A long-lasting decrease in CD200R1 and/or CD200 protein expression in the midbrain has also been reported in other in vivo experimental models of PD, such as the LPS model and the adenovirus-induced overexpression of human α-synuclein in SNpc [79] and the 6-OHDA rat model [56]. The gene discussed is CD200R1; the disease is Parkinson disease.