Another novel coinhibitory receptor, LAG-3, which negatively regulates T-cell activation, has been reported to be present at a lower expression rate (18%) in early-stage TNBC as compared to PD-1 expression on TILs (30%), whereas coexpression of both receptors was found in 15.4% of breast-tumor-associated TILs [39]. The gene discussed is PDCD1; the disease is breast neoplasm.