HAVCR2 and neoplasm: Expression of PD-1 has also shown significant correlations with CTLA-4 (p < 0.001) and TIM-3 on TILs (p = 0.001), whereas CTLA-4 expression on TILs correlated with CTLA-4 expression on the tumor (p < 0.001) and TIM-3 expression on TILs (p = 0.018).