F2 and cancer: This dataset included 1 variant in OPTC associated with glaucoma [62], 2 variants in NKX2-5 associated with congenital heart defects [64], 1 variant in DRD2 associated with post-traumatic stress disorder [60], 2 variants in COMT associated with pain sensitivity [61], 1 variant in F2 (prothrombin) associated with thrombosis [90], and 2 variants linked to cancer in KRAS [71] and TP53 [91].