HAVCR2 and autoimmune disease: Previously, the putative role of Tim-3 in immunological tolerance and autoimmune diseases has been characterized in several Th1 mediated animal models: In EAE, anti-Tim-3 treatment resulted in a peracute onset of disease potentially mediated via cross-linking differentiated Th1 cells and increasing their migration which in turn led to enhanced cytokine production and macrophage activation [13].