VWF and pulmonary arterial hypertension: Downregulation of genes associated with cardiac function edema and blood clotting–atrial natriuretic factor precursor (0.54-fold), myosin regulatory light chain 2 smooth muscle isoform (0.52-fold), heparin cofactor 2 precursor (0.51-fold), Von Willebrand factor precursor (0.75 fold), and sodium/potassium-transporting ATPase (0.57-fold)–correlate with PAH-induced cardiomyopathy, pericardial edema, and dysregulation of blood clotting mechanisms, all evident in sensitive embryos exposed to polluted sediment extract (Fig 3A).