Consistent with their high entropy, CD44hi IPF MPCs displayed higher protein levels of pluripotency transcription factors Oct3/4 (23% higher), Nanog (13% higher), and Sox2 (61% higher) (Figure 4A) as well as greater self-renewal capacity (Figure 4B) compared with CD44lo IPF MPCs. Here, POU5F1 is linked to idiopathic pulmonary fibrosis.