However, till date, the mechanism by which SGK1 controls the anti‐leukemic effect of glucocorticoids has remained unknown and for that reason the SGK1/FBXW7/N1‐ICD trimeric complex may represent a potential therapeutic target for improving the efficiency of anti‐leukemic therapies in T‐ALL tumors expressing NOTCH1.51 Here, FBXW7 is linked to acute lymphoblastic leukemia.