Several signaling pathways have been attributed to play a key role in NSCLC chemoresistance including NOTCH‐1, JAK/STAT, PI3K/Akt, Wnt, TGF‐β, etc. There exists a strong correlation between FBXW7, NOTCH, and miR‐223 in mediating NSCLC resistance against the drug erlotinib. Here, FBXW7 is linked to non-small cell lung carcinoma.