While these observations do indicate that IKAROS suppresses the NOTCH1 activation and subsequent transcription of downstream target genes like Hes‐1 in thymocytes, the precise role of FBXW7 mutations in these IKAROS‐mediated processes needs to be investigated further in T‐ALL tumors.27, 37. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.