IL6 and Sepsis: Moreover, serum IL‐6 level is positively correlated with the serum levels of PAI‐1 in patients with cytokine release syndrome (CRS), including those with sepsis or ARDS, and the IL‐6 trans‐signaling–PAI‐1 axis is also critical for the pathogenesis of COVID‐19‐induced CRS, which leads to endotheliopathy and coagulopathy (Kang et al., 2020).