In conclusion, we report here that concurrence of CSF3RT618I, ASXL1, SETBP1, and SRSF2 mutations may co-contribute to AML transformation, but their interactions with PRKDC and MYOM2 mutations in the pathogenesis of CNL as well as their prognostic implications remain to be determined. Here, SRSF2 is linked to chronic neutrophilic leukemia.