NLRP3 and colon adenocarcinoma: IOD results further confirmed that NLRP3 was significantly higher in colon adenocarcinoma tissues compared to the normal colons in both HCT116 xenografts (Figure 2A, 1.95 ± 0.43 vs. 1.00 ± 0.28, P=0.035) and RKO xenografts (Figure 2C, 2.52 ± 0.43 vs. 1.00 ± 0.25, P=0.003).