NLRP3 and colon adenocarcinoma: Consistently, the protein level detected by Western blot revealed a similar pattern that NLRP3 was substantially increased in colon adenocarcinoma tissues compared with the normal colon in both HCT116 xenografts (Figure 2B, 2.12 ± 0.35 vs. 1.00 ± 0.14, P=0.018) and RKO xenografts (Figure 2D, 2.62 ± 0.43 vs. 1.00 ± 0.17, P=0.011).