NLRP3 and colon adenocarcinoma: Compared with previous clinical or animal researches concerning NLRP3, we are the first to apply survival analysis and multivariable Cox proportional hazards regression model to evaluate the prognostic effect of NLRP3 in colon adenocarcinoma and discovered a novel result that NLRP3 is an independent risk factor for the prognosis of CRC patients.