Hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates the expression of several genes, including antioxidant enzymes, has been associated with a variety of cancers as well as with HCC (Cheng et al., 2015; Menegon et al., 2016; Ma-on et al., 2017; Sajadimajd and Khazaei, 2017). Here, NFE2L2 is linked to cancer.