Alternatively, treatment of BRAF mutant colorectal cancer models with MAPK inhibitors stimulated WNT pathway through the activation of cytoplasmic focal adhesion kinase (FAK) (Chen et al., 2018) or depletion of AXIN1 protein (Zhan et al., 2019), resulting in the stabilization of β-catenin. This evidence concerns the gene PTK2 and colorectal cancer.