Although we find no evidence for the above three mechanisms as mediators of ERK/WNT cross-regulation in our lung tumor model, we did identify three candidate genes induced by MAPK inhibition (whole-tumor and single cell RNA-seq) that might account for the increased WNT signaling: Dixdc1, Sox4 and Sox9 (Figure 7A). The gene discussed is MAPK1; the disease is neoplasm.