RNF157 and metabolic disease: In our hypernetwork model, the expression of miR-122-5p was correlated with clusters of genes that were centrally coordinated by expression of both RNF157 and TBXAS1, the former suggested to be a key regulator of both PI3K and MAPK signaling pathways, commonly perturbated in cancer and metabolic disorders (Dogan et al., 2017).