While Pbk/TOPK was reported to phosphorylate several protein substrates including p53‐related protein kinase (PRPK) in colorectal cancer cells (Zykova et al,2017) and Cdk1/cyclin B1/PRC1 kinase substrate complex (Abe et al,2007), our preliminary in vitro studies did not detect obvious phosphorylation of menin or JunD by Pbk using the anti‐menin S487 phosphorylation antibody or anti‐JunD S100 antibody, respectively (data not shown). This evidence concerns the gene PBK and colorectal cancer.