DMD and Duchenne muscular dystrophy: However, detailed knowledge of the disease model is vital for interpreting data: A study in the mdx mouse model for DMD of the PK/PD of 2ʹ‐OMe ONs for DMD revealed higher ON levels in dystrophin‐deficient muscle fibres than in healthy fibres, as well as an enhanced exon skipping efficiency (Heemskerk et al,2010).