Stimulating of BV2 microglial cells by LPS lead to the production of pro-inflammatory cytokines, such as IL-1β, IL-6 and TNF-α, which have been confirmed that could cause neural cell damage, initiate and amplify the inflammatory response, and lead to the development of neurodegenerative diseases [29]; Therefore, the suppression of their production is pivotal for prevention of neurodegenerative diseases [2, 11]. This evidence concerns the gene IL1B and neurodegenerative disease.