Within all studies, PI3Kγ-deficient mice are healthy and viable with reduced allergic AHR, inflammation, and remodelling. In the absence of PI3Kγ, the chemokine-induced model of airway inflammation displays impaired neutrophils, eosinophils and macrophages chemotaxis, reduced peribronchial fibrosis and TGF-β1+ cells and lower Smad 2/3 signaling. Here, TGFB1 is linked to inflammation.