The aim of this study was to explore the significance of KPNA2 in human six major cancers including non-small cell lung cancer (NSCLC), gastric cancer, colorectal cancer, breast cancer, hepatocellular carcinoma, and bladder cancer based on bioinformatics analysis.<h4>Methods</h4>The data were collected and comprehensively analyzed based on multiple databases. The gene discussed is KPNA2; the disease is hepatocellular carcinoma.