It has been reported that miR-144-3p plays different roles in various diseases and promotes tumor growth and metastasis of papillary thyroid carcinoma by targeting the paired box gene 8 [27]; However, it serves as a tumor suppressor in renal cell carcinoma and inhibits its invasion and metastasis by targeting MAP3K8, also a tumor suppressor, by targeting FZD7. The gene discussed is MAP3K8; the disease is thyroid gland papillary carcinoma.