CD8A and neoplasm: This same study created a tumor-harboring mouse model with these characteristics, and elucidated that therapeutic inhibition of TGF-beta in conjunction with anti-PD-L1 antibodies led to reversal of the observed phenotype: reduction of TGF-beta expression in tumor stromal cells, increased tumor infiltration by CD8+ T cells, and enhanced generation of antitumor immune responses [84].