To analyse the role of p75NTR in proNGF-promoting pancreatic cancer cell migration and invasion, Panc-1 and Capan-1 cells were divided into 3 groups: OE-NC + si-NC, OE-proNGF + si-NC and OE-proNGF + si-NGFR. Here, NGFR is linked to familial pancreatic carcinoma.