To analyse the effects of miR-186-5p targeting NGFR on pancreatic cancer cells, Panc-1 and Capan-1 cells were divided into 4 groups: si-NC + inhibitor-NC, si-NC + inhibitor-miR-186-5p, si-NGFR + inhibitor-miR-186-5p and si-NGFR + inhibitor-NC. The gene discussed is NGFR; the disease is pancreatic neoplasm.