CD4 and hepatocellular carcinoma: Although higher myeloid-derived suppressor cells (MDSCs) infiltration and lower Tregs infiltration associated with improved OS (Figure 8G, 8H), MDSCs (HR = 0.730, p = 0.307) and Tregs (HR = 0.966, p = 0.647) (Table 5) which are significantly associated with bad prognosis in other cancer [39] were not hazard risk (Table 5) for HCC in our study, and we also don’t observed separation of the MDSCs and Tregs subpopulations related to immune suppression from the subpopulations related to the effector function (activated T cells, Tcm, Tem CD4+ and CD8+ cells) (Figure 9B, 9C).