There was a significant decrease in the number of tumor cells (EpCAM+, PD-L1+) and M2 like macrophages (CD11b+CD64+CD206+ and CD11b+CD64+CD163+) with PD-L1 BiTE treatment, alongside a significant increase in activated T cells number (CD3+ and CD25+) (online supplemental figure 17 and 18). This evidence concerns the gene ITGAM and neoplasm.