CD274 and cancer: Previous studies have shown that TAMs promote cancer cell proliferation, invasion, metastasis and production of immune-suppressive molecules.35 In particular, TAMs exhibiting an M2-like phenotype are directly involved in T cell suppression by expressing surface PD-L1.35 To determine whether PD-L1 BiTE can target T cells to TAMs, we differentiated human monocytes to macrophages and polarized them to an M2-like phenotype.