We observed both tumor cells (EpCAM+) and M2 macrophages (CD11b+) positive for oHSV-1 (GFP+), producing active PD-L1 BiTE (online supplemental figures 11B–D and 14A) and mediating significant increase in number of CD3+ cells but decrease in tumor and M2-like macrophages (online supplemental figure 14B). The gene discussed is ITGAM; the disease is neoplasm.