INS and metabolic disease: Currently, replacement gilts are typically fed ad libitum, however, a growing body of evidence reveals that this free eating pattern is associated with an increased prevalence of metabolic diseases in humans and rodents [6–8], and in contrast, studies of laboratory animals and humans have shown that a decreased meal frequency (MF) can increase insulin sensitivity and thereby reduce obesity related metabolic diseases, and even extend the lifespan [7–9].