The results showed that BC patients with high NEAT1 expression in serum EVs had higher lymph node metastasis rate, progesterone receptor (PR) positive rate, estrogen receptor (ER) positive rate and Ki-67 positive rate (all p < 0.05), but NEAT1 expression in serum EVs was not significantly related to the age, tumor size and clinical stage (all p > 0.05) (Table 2). This evidence concerns the gene ESR1 and neoplasm.