Using the clinical model which included Pitt bacteremia score ≥ 4 and septic shock (AUC = 0.801, 95% CI 0.690, 0.912), and quartile 2 as the reference group, the addition of Day 4 IL-10 quartiles (p = 0.03), but not Day 4 TNF quartiles (p = 0.07), significantly improved model performance. Here, TNF is linked to bacterial infectious disease with sepsis.