The sensitivity and specificity values of serum NSE (cut-off value 40.0 μg/L) as a predictor of moderate to severe HIE were 79% and 70%, respectively, and as a predictor of poor outcomes (cut-off value 45.4 μg/L) it had a sensitivity of 84% and a specificity of 70% [25]. Here, ENO2 is linked to perinatal asphyxia.