Chronic pruritus was associated with individual increased epidermal TRPV4 expression, and these patients had increased responses to capsaicin, including pruritus and burning/warmth sensation.38 This finding, namely, that increased TRPV4 expression in pruritic skin sensitizes TRPV1 signaling in sensory neurons, appears in agreement with our study. This evidence concerns the gene TRPV4 and Pruritus.