TRPV1 and Pruritus: Chronic pruritus was associated with individual increased epidermal TRPV4 expression, and these patients had increased responses to capsaicin, including pruritus and burning/warmth sensation.38 This finding, namely, that increased TRPV4 expression in pruritic skin sensitizes TRPV1 signaling in sensory neurons, appears in agreement with our study.