miRNAs are small, highly conserved, noncoding RNA molecules with known roles in RNA silencing and posttranscriptional regulation of gene expression.39 Interestingly, recent work discovered an unconventional role for miRs: they can either directly or indirectly activate TRPA1 in sensory neurons to induce itch or pain.27,28 miR-146a has been found immunomodulatory in inflammation with postulated proresolution roles in psoriasis and atopic dermatitis, both of which are pruritic.29,30,40. This evidence concerns the gene TRPA1 and psoriasis.