NUMB and colorectal cancer: A role for miR-146 in CSCs has been described in colorectal cancer, where it promotes a symmetric mode of division through the Snail/miR-146a/β-catenin/Numb axis (Hwang et al., 2014), and in glioma, where it was shown to inhibit neurosphere formation and tumor development by targeting NOTCH1 (Mei et al., 2011).