In comparing expression levels of each of the genes in the same TCGA datasets as in Fig 1b, we find that overall ENG is the most highly expressed gene (Fig 1c) with variance among different cancer types (e.g., lower-grade glioma and cervical vs. renal clear cell and lung adenocarcinoma, p < 0.0001) and subtypes (e.g., luminal A vs. luminal B breast cancers, p < 0.0001). This evidence concerns the gene ENG and central nervous system cancer.