CLN5 and neoplasm: Given that TGF-β’s BMPs, Wnt, and FGF can act as both tumor suppressors and promoters in a cancer and context dependent manner, and our analysis indicating that ENG and TGFBR3 are both strong predictors of survival on their own (Fig 2) it is likely that ENG and TGFBR3 expression levels impact signaling sensitivity and thereby patient outcomes in the context of those signaling ligands.