TGFBR3 and cancer: To begin to evaluate the impact of this relationship more broadly in cancers we analyzed gene alterations including mutations, amplifications, and deletions for the genes encoding inhibin/activin subunits (Fig 1a) INHA, INHBA, INHBB, and the key coreceptors—TGFBR3, and ENG in all public datasets available in cBioPortal (Fig 1b, S1 Table).