Interestingly, genes connecting pairs of 16p11.2 genes were enriched for genes intolerant to functional variation (Fig 7E and 7G), such as ASH1L, a histone methyltransferase activator and autism candidate gene [77], and CAMK2B, a protein kinase gene causative for intellectual disability [78]. The gene discussed is PRDM9; the disease is Intellectual disability.