For example, ssc_circ_009380 promoted activation of NF-κB pathway by binding miR-22 during Transmissible gastroenteritis virus (TGEV)-induced inflammation [24]; circUBAP2-mediated ceRNA network modulated pancreatic adenocarcinoma by regulating NF-κB signaling pathway and the function of immune cells [25]; circ_0075932 directly bound with the RNA-binding protein PUM2, which was reported to positively regulated AuroraA kinase, thus activating the NF-κB pathway to display a significantly promoting effect on inflammation and apoptosis in dermal keratinocytes [26]. The gene discussed is PUM2; the disease is pancreatic adenocarcinoma.