SIX3 and nervous system disorder: The mRNAs of Rgs9, Gpr88, Drd2, Sh3rf2, Tac1, Serpina 9, Rxrg, Drd1, Rasgrp2, Six3, Gpr6, Pdyn, Gng7, and Pde1b were all upregulated (Figure 4A and Table 1; p < 0.05); all of these have been reported to be more or less related to nervous system diseases.