Research further indicates that exenatide reverts the adverse changes to brain derived neurotrophic factor (BDNF) signaling and to the neuroinflammatory status of 3xTg-AD (APPSwe, tauP301L)1Lfa/J) mice receiving a HFD, without affecting systemic metabolism or promoting changes in cognitive performance [35]. This evidence concerns the gene BDNF and Alzheimer disease.