In the present study, we found that some genes of benefit to nervous system disease were activated (such as Lhx8, GPR88, RGS9, CD4, DRD2, RXRG, and Syt6), following the increase in the number of cholinergic and GABAergic neurons in the HSHF-diet offspring (Figure 4). The gene discussed is DRD2; the disease is nervous system disorder.