PROM1 and malignant colon neoplasm: Our results demonstrated that compared to the control CD133+CD44+ CCSCs, colon cancer cells from PRDX2 knockdown CD133+CD44+ CCSCs exhibited reduced tumor incidence, tumor size and tumor growth in vivo (Figure 3), suggesting that PRDX2 knockdown significantly suppresses the tumorigenic capacity of CD133+CD44+ CCSCs in vivo.